Validation of the Kohnen Restless Legs Syndrome–Quality of Life instrument

•The Kohnen Restless Legs Syndrome–Quality of Life questionnaire (KRLS-QoL) is a specific 12-item instrument self-applied by RLS patients to measure quality of life.•The present study is aimed at performing a first formal validation study of this instrument.•The KRLS-QoL performed as an acceptable, reliable, valid, and responsive measure to assess the impact of the RLS on quality of life.•The KRLS-QoL performs comparably to other RLS QoL scales and can be used to measure responsiveness to therapy.