Epigenetic features of FoxP3 in children with cow’s milk allergy

Lorella Paparo,Rita Nocerino,Linda Cosenza,Rosita Aitoro,Valeria D’Argenio,Valentina Del Monaco,Carmen Di Scala,Antonio Amoroso,Margherita Di Costanzo,Francesco Salvatore,Roberto Berni Canani

Clinical Epigenetics（2016）

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摘要

DNA methylation of the Th1 and Th2 cytokine genes is altered during cow’s milk allergy (CMA). Forkhead box transcription factor 3 (FoxP3) is essential for the development and function of regulatory T cells (Tregs) and is involved in oral tolerance acquisition. We assessed whether tolerance acquisition in children with IgE-mediated CMA is associated with DNA demethylation of the Treg-specific demethylated region (TSDR) of FoxP3.

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关键词

Food allergy,Extensively hydrolyzed casein formula,Oral tolerance,Lactobacillus rhamnosus GG

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