Synthesis of N,N′-Dialkylated Cyclohexane-1,2-diamines and Their Application As Asymmetric Ligands and Organocatalysts for the Synthesis of Alcohols

A series of N,N'-dialkylated derivatives of (1R, 2R)-cyclohexane-1,2-diamine were synthesized, and a new approach to the one-pot preparation of this type of amine was demonstrated. The prepared diamines were used as organocatalysts for the two-step synthesis of ahydroxy gamma-keto esters from arenes, chlorooxoacetates, and ketones; they were also used as chiral ligands for Meervein-Ponndorf-Verley reductions and Henry reactions.