Preclinical activity of FF-10501-01, a novel inosine-5′-monophosphate dehydrogenase inhibitor, in acute myeloid leukemia

Hui Yang,Zhihong Fang,Yue Wei,Zachary S. Bohannan,Irene Gañán-Gómez,Ana Alfonso Pierola,Linda J. Paradiso,Hiroyuki Iwamura,Guillermo Garcia-Manero

Leukemia Research（2017）

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摘要

•FF-10501-01 induces AML leukemic cell death and reduces cell proliferation.•FF-10501-01 shows strong anti-leukemia effect regardless of HMA resistance status.•FF-10501-01 functions through targeting guanine nucleotide biosynthesis.

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关键词

Acute myeloid leukemia,IMPDH,HMA resistance,Guanosine,Metabolic inhibitor

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