MANAGEMENT AND OUTCOMES OF ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODY-ASSOCIATED VASCULITIS IN UNSELECTED CASES WITHIN A LARGE HEALTH REGION OF ENGLAND

Background: Most ANCA-associated vasculitis (AAV) outcome data derives from highly-selected tertiary centres or clinical trials. These results may not be generalizable to routine practice.Methods: Rheumatology and Renal units within Midlands and East of England were invited to undertake retrospective case-note audit of patients newly-diagnosed with AAV between April 2013-December 2014. Data were collected on time to diagnosis and treatment, systems involved, remission-induction, and outcomes. Odds ratio (OR) for infection estimated using logistic regression, and hazard ratio (HR) for death estimated using cox regression were both adjusted for confounders (age, renal involvement).Results: Cases were contributed by 20 (59%) of 34 units (Table 1). A cohort of 130 newly-diagnosed adult patients were identified in an adult catchment population of 6,980,000. This equates to incidence...