PPARβ/δ: A Key Therapeutic Target in Metabolic Disorders

Research in recent years on peroxisome proliferator-activated receptor (PPAR)beta/delta indicates that it plays a key role in the maintenance of energy homeostasis, both at the cellular level and within the organism as a whole. PPAR beta/delta activation might help prevent the development of metabolic disorders, including obesity, dyslipidaemia, type 2 diabetes mellitus and non-alcoholic fatty liver disease. This review highlights research findings on the PPAR beta/delta regulation of energy metabolism and the development of diseases related to altered cellular and body metabolism. It also describes the potential of the pharmacological activation of PPAR beta/delta as a treatment for human metabolic disorders.