Synthesis, structures and antimicrobial activity of novel NHC∗- and Ph3P-Ag(I)-Benzoate derivatives

Cillian O'Beirne, Nada F. Alhamad, Qinxi Ma,Helge Müller-Bunz,Kevin Kavanagh,Geraldine Butler,Xiangming Zhu,Matthias Tacke

Inorganica Chimica Acta（2019）

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摘要

Synthesis, crystal structure data and biological evaluation of four novel NHC∗-Ag(I)-Benzoate and four novel Triphenyl Phosphine Ag(I)-Benzoate complexes against Methicillin-Resistant Staphylococcus aureus (MRSA), Escherichia coli, Candida parapsilosis and Candida albicans, with antifungal data indicating several complexes can complete with medicinal grade antifungal agents.

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关键词

N-Heterocyclic carbenes,NHC-silver(I) complex,MRSA,Candida,Crystal structures,Antimicrobial resistance

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