The Osteocalcin Was Independently Associated With Systolic Blood Pressure In The Chinese Women

Objectives: Our study aimed to examine the relationship between the bone formation marker OCN and blood pressure in humans. Methods: Serum OCN, fasting plasma glucose, and 2 h post-challenge glucose levels during oral glucose tolerance test, fasting insulin, glycated hemoglobin A1c (HbA1c), hepatic and renal functions, electrolytes and anthropometric parameters were measured. Results: OCN was positively associated with SBP after adjustments for multiple confounding factors (r = 0.23, p = .003). age (β = 0.094,P = .005), BMI (β = −0.498,P = .005), and SBP (β = 0.132,P = .029) were the major determinants of the variations of OCN (adjusted R2 for the model = 0.608, P = .01). When SBP was used as a dependent variable, it was demonstrated that age (β = 0.344,P = .001), weight (β = 0.303,P = .001), FPG OCN (β = 0.209,P = .049), could enter the regression model (adjusted R2 for the model = 0.420, P = .028).Compared with those in the lowest SBP group, increase in OCN between the groups (P for trend = .001), with the highest OCN levels observed in subjects in the highest SBP group even when multiple confounders were adjusted (P for trend = .015). Conclusion: Bone formation marker serum OCN was independently associated with systolic blood pressure (SBP) in NGT and NBP women. Whether the increased OCN level in NGT and NBP subjects is an early marker predicting the subtle impairment of blood pressure and the risk of occurrence of hypertension requires additional study.