Abstract 13133: The Association of Coronary Artery Calcification (CAC) With Subsequent Cardiovascular Disease (CVD) in DCCT/EDIC

Introduction: The coronary artery calcium (CAC)-score has been validated to improve risk assessments for future cardiovascular events in general populations; however, this association has not been well-studied in type 1 diabetes (T1D). Objectives: To determine the relationship of CAC-scores with subsequent cardiovascular disease (CVD) and major adverse cardiovascular event (MACE) in DCCT/EDIC participants. Methods: Computed tomography (CT) to measure CAC was performed in 1205 DCCT/EDIC participants (mean age of 42.8 years) in 2001-2003. In this study, we analyzed the association between those CAC-scores and the time to the first subsequent CVD and MACE event over the next 13 years. CVD event included non-fatal myocardial infarction or stroke, cardiovascular death, silent myocardial infarction, angina pectoris, congestive heart failure, or revascularization and MACE event included non-fatal MI, non-fatal stroke, or cardiovascular death. Forty-nine participants with a prior CVD including 18 with a prior MAC...