Effect of mesopores on solidification of sirolimus self-microemulsifying drug delivery system

Chun Tao, Yue Yu,Zhenzhen Chen,Minxin Zhang, Linlin Liu,Zhihong Liu,Jialiang Zhang,Qian Zhang,Hongtao Song

Chinese Chemical Letters（2018）

引用 9|浏览9

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摘要

The mesoporous silica materials had a high loading efficiency of sirolimus-SMEDDS. The length of the mesopores played a more important role than the pore diameter in drug dissolution and in vivo absorption.

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关键词

Mesopores,Mesoporous silica nanospheres,SBA-15,Self-microemulsifying drug delivery system,Sirolimus,Bioavailability

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