A practical synthesis of functionalized isoindolinones via [3 + 3] benzannulation of 1,3-bissulfonylpropenes and 4-arylmethylene-2,3-dioxopyrrolidines

Xiang-zheng Tang,Jing-xuan zhou,Hua-ju Liang,Xue-jing Zhang,Ming Yan,Albert S.C. Chan

Tetrahedron Letters（2019）

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摘要

•Novel and practical synthesis of functionalized isoindolinones.•Excellent yields, simple procedure and mild reaction conditions.•Gram-scale reaction without transition metal catalyst.•Diversified transformations of the products.

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关键词

Isoindolinone,[3+3]Benzannulation,1,3-Bissulfonylpropene,4-Arylmethylene-2,3-dioxopyrrolidine,4-Sulfonylcrotonate

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