Indium(III) Triflate‐Catalyzed Glycosylation through an Ambient Activation of Glycosyl Fluoride

A highly efficient catalytic glycosylation using glycosyl fluoride in the presence of a mild and non-toxic Lewis acid, indium(III) triflate, was achieved. The facile and convenient glycosylation procedure does not require pre-activation steps, pre-distillation, or cumbersome work-up process, and it was compatible with a broad range of alcohol acceptors under ambient conditions. Furthermore, the stereoselective C-glycosylation smoothly proceeded under the same conditions.