Temporal Patterns Of 7 Blood Biomarkers Of Cardiac Remodeling In Relation To Prognosis Of Patients With Chronic Heart Failure - The Bio-Shift Study

Introduction: Remodeling biomarkers carry high potential for predicting adverse events in chronic heart failure(CHF) patients. However, detailed temporal patterns of these biomarkers during the course of CHF, and especially the temporal trajectory shortly before an adverse event occurs, remain unknown. Methods: In 263 patients, blood samples were collected at three month intervals during a median follow-up of 2.2 (IQR:1.4-2.5) years (median(IQR): 9(5-10) samples per patient). For efficiency, we selected all baseline samples, the two samples closest to a primary endpoint(PE), and the last sample available for event-free patients. Thus, in 567 samples we measured ST2, galectin-3(Gal-3), growth differentiation factor 15(GDF-15), matrix metalloproteinase(MMP)-2, 3 and 9, aminopeptidase-N(APN), and NT-proBNP using an Olink Proteomics multiplex assay. PE comprised the composite of cardiac death, cardiac transplantation, LVAD implantation and HF hospitalization. Associations between biomarkers and first PE were ...