The Changes of Plasma Amino Acids and Lipid Profiles in Patients with Cystic Fibrosis and Malnutrition induced by Immunonutrition

Background: According to the previous report immunonutrition leads to serum amyloid a decline in the cystic fibrosis patients with malnutrition. The goal of the current study was to evaluate the immunonutrition influence on nutrition parameters, plasma amino acid and lipid profiles in cystic fibrosis patients complicated with malnutrition. Methods: The changes of nutrition parameters and lipid and plasma amino acids profiles induced by immunonutrition and standard nutrition sipping were evaluated in 30 patients with cystic fibrosis in comparison with 55 control healthy subjects. Results: BMI, plasma prealbumin, transferrin were significantly deteriorated in patients with cystic fibrosis as well as plasma amino acids and lipid profiles in comparison with control subjects. Serum level of triacylgycerols significantly decreased in the cystic fibrosis patients after immunonutrion support. Immunonutrition lead to the elevation of glutamic acid, methionine, arginine and ornithine plasma concentration while the plasma concentration of glutamine, glycine, valine, threonine and tryptophan significantly decreased. Conclusion: Immunonutrition leads to the significant decrease of serum triacylglycerols and to the changes in plasma amino acids profile in the cystic fibrosis patients with malnutrition that may reflect an activation of immune system.