Alkyne-Forming Furan Fragmentation: A General Method to Convert Furans into Alkynoic Acids
SYNLETT(2019)
摘要
Furans are readily available and highly reactive heterocycles that serve as versatile four-carbon synthons in organic synthesis. Recently, we discovered that furans, upon oxidation with singlet oxygen, can be transformed into alkynes via dual C-C double-bond cleavage. This Synpacts article presents an overview of the historical context and the development of this furan fragmentation reaction. We also discuss its application in natural product synthesis and a plausible reaction mechanism. 1 Introduction 2 Background of Alkyne-Forming Furan Fragmentation 3Reaction Development 4 Conclusion
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关键词
furans,alkynes,singlet oxygen,fragmentation,cycloaddition,ring strain,natural products
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