Abstract 16472: Cardiac Biomarkers Are Associated With Death and Listing for Heart Transplantation in Pediatric Patients With Newly Diagnosed Dilated Cardiomyopathy: A Multi-Center Study From the Pediatric Cardiomyopathy Registry
Circulation(2017)
摘要
Background: Children with dilated cardiomyopathy (DCM) are at high risk for morbidity and death. There are no validated serum biomarkers associated with clinical events. Objective: To evaluate cardiac biomarkers as predictors of clinical endpoints (heart failure, death, or transplant listing, heart transplant). Design / Methods: Patients (u003c21 years of age at DCM diagnosis) were enrolled at 15 North American pediatric cardiomyopathy centers within one year of diagnosis with collection of serum, echocardiograms and clinical data at enrollment and at intervals for up to 2 years. The main hypothesis was that heart failure, myocyte injury, and inflammatory biomarkers are associated with the primary study endpoint (heart failure, death, or transplant listing, or heart transplant) u003c90 days of enrollment. Results: Data from 74 subjects were analyzed, median age 2.1 years at enrollment [interquartile range (IQR 0.7-12.8)], 44 (55%) female, and 61 (76%) enrolled within 90 days of diagnosis. The primary endpoint was...
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关键词
Cardiomyopathy,Pediatric cardiology,Acute heart failure,Biomarkers
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