Epigenome-Wide Association Study Of Measures Of Fasting Glucose, Fasting Insulin, And Hba1c In Non-Diabetic Individuals Of European, African, And Hispanic Ancestry In The Charge Consortium

Background: Fasting glucose, fasting insulin, and hemoglobin A1c are important glycemic biomarkers and elevated levels of these markers predict future glycemic dysfunction and type-2 diabetes. Several studies have identified DNA methylation sites associated with quantitative glycemic traits and T2D. However, these studies have generally been limited in size. In this project, we aim to identify blood cells methylation signatures associated with three quantitative glycemic traits - fasting glucose (FG), log-transformed fasting insulin (logFI) and hemoglobinA1c (HbA1c) through meta-analysis of DNA methylation data from participating CHARGE Epigenetics Working Group cohorts. Methods: We conducted a epigenome-wide meta-analysis of DNA methylation assessed with Illumina BeadChip 450K array on blood-based DNA samples, including 12,681 for FG, 11,224 for logFI, and 6358 for HbA1c, from non-diabetic participants of European, African, and Hispanic ancestry in 10 cohorts from the CHARGE Epigenetics Working Group. Mi...