Vaccination against babesiosis using recombinant GPI-anchored proteins

Sarah Nathaly Wieser,Leonhard Schnittger,Monica Florin-Christensen,Stephane Delbecq,Theo Schetters

International Journal for Parasitology（2019）

引用 25|浏览10

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摘要

•GPI-anchored merozoite proteins of Babesia can be effective vaccine antigens.•Selected recombinant merozoite surface proteins can be used to induce immunity.•The 3D structure of recombinant proteins is important for the induction of immunity.•Babesia microti has the machinery to assemble GPI-anchored proteins.•Babesia microti encodes for 21 GPI-anchored proteins.

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关键词

Babesia microti,Babesia divergens,Recombinant vaccine,GPI anchors,Apicomplexa,Human babesiosis,Merozoite surface protein

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