Hyperinsulinemia Disrupts Vascular Homeostasis, Enhances Oxidative Stress and Impairs Flow Induced Dilation of Human Skeletal Muscle Arterioles

Abeer M. Mahmoud,Mary R. Szczurek,Austin T. Robinson,Jacob T. Mey, Brian K. Blackburn,Jing-Tan Bian,Michael D. Brown,Phillips A. Shane,Jacob M. Haus

Circulation（2014）

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摘要

Insulin resistance promotes vascular endothelial dysfunction (VED) and subsequent development of cardiovascular disease. At physiological levels, insulin maintains balance between vasodilators, mai...

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关键词

Endothelial function,Insulin,Insulin resistance,Muscle, skeletal,Nitric oxide

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