Abstract 18949: Associations of Physical Activity Levels, Body Mass Index, and Risks of Heart Failure With Preserved Ejection Fraction vs. Reduced Ejection Fraction: An Individual-Level Pooled Analysis

Introduction: Low levels of physical activity (PA) and higher BMI have each been associated independently with risk of HF. However, it is unclear if this relationship is consistent for the two HF subtypes, HFpEF and HFrEF. Methods: Individual-level data from three cohort studies WHI, MESA, and CHS were pooled and participants were stratified into guideline recommended categories of PA and BMI. Separate multivariable-adjusted Cox proportional hazards regression models were constructed to determine the association of BMI and PA level categories with risk of overall HF, HFpEF (EF u003e45%) and HFrEF (EF ≤ 45%) with land-marking of HF outcomes in the first 2 years of follow-up. Continuous associations between PA, BMI and outcomes were assessed using restricted cubic splines. Results: A total of 51,498 participants with 2,834 HF events were included (1,248 HFpEF, 912 HFrEF, 674 HF events with missing EF). In adjusted analysis, there was a dose-dependent association between higher PA levels, lower BMI and risk of H...