LRSAM1 E3 ubiquitin ligase: molecular neurobiological perspectives linked with brain diseases

Ribhav Mishra
Ribhav Mishra
Rohan Dhiman
Rohan Dhiman
Nihar Ranjan Jana
Nihar Ranjan Jana

Cellular and Molecular Life Sciences, pp. 2093-2110, 2019.

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Keywords:
LRSAM1 Chaperone Misfolded proteins Neurodegeneration

Abstract:

Cellular protein quality control (PQC) plays a significant role in the maintenance of cellular homeostasis. Failure of PQC mechanism may lead to various neurodegenerative diseases due to accumulation of aberrant proteins. To avoid such fatal neuronal conditions PQC employs autophagy and ubiquitin proteasome system (UPS) to degrade misfold...More

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