Synthesis of 5-substituted and 5,6-disubstituted furo[2,3-d]pyrimidines from 2-methylthio-4,6-pyrimidindione and bifunctional electrophiles

Gražina Petraitytė,Vytenis Vaitkevičius,Besra Özer,Viktoras Masevičius

Tetrahedron Letters（2019）

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摘要

•5-substituted furo[2,3-d]pyrimidines from pyrimidines and bifunctional electrophiles.•Silica gel is a “solvent” of choice for intramolecular reactions at high temperature.•Lactam-lactim tautomerism can be source of unaccounted carbons in 13C NMR spectra.

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