Abstract P236: Analysison Time Course Changes of Adipocytokine Levels and Abdominal Obesity afterQuitting Smoking

Background: Adipocytokines are produced and secreted by the adipose tissue and are strongly associated with obesity. Among these cytokines, adiponectin prevents arteriosclerosis. In obesity, the serum adiponectin levels decrease whereas leptin levels increase. However, the association between these two adipocytokines and abdominal obesity after smoking cessation is unknown. Purpose: The present study investigated time-dependent changes after smoking cessation of two adipocytokines, adiponectin and leptin, as well as the changes of body mass index and waist circumstance (WC). Methods: All anti-smoking treatments were conducted according to the Standard Procedures for Anti-Smoking Treatment (originally issued in March 2006 by the Japanese Circulation Society, Japan Lung Cancer Society, and Japanese Cancer Association). The patients were treated with transdermal nicotine patches or the oral administration of varenicline. Among patients who attended our smoking cessation clinic, 56 (37 males and 19 females) successfully quit smoking. We measured their serum leptin and adiponectin levels at baseline, 3 months, and 1 year after beginning smoking cessation. Moreover, the changes in data from before to 3 months and 1 year after smoking cessation were compared by unpaired t-test between patients with a WC increase smaller than the median and those with a WC increase greater than the median. Results: Body mass index and WC significantly increased from baseline to 3 months to 1 year after beginning smoking cessation. The leptin level significantly increased (5.0 ng/ml → 6.2 ng/ml (p < 0.05) → 7.1 ng/ml (p < 0.001)) in proportion to the weight gain. Adiponectin levels, however, did not change after smoking cessation. Using the median ΔWC (+1.8 %) as the cutoff point, patients were divided into two groups. The percent change in adiponectin level from baseline to 1 year was significantly greater in the ΔWC < median group (+13.4 %) than in the ΔWC ≧ median group (-0.6 %) (p = 0.028). Conclusion: Despite weight gain and increased abdominal obesity, serum adiponectin levels did not decrease after smoking cessation. Rather, they increased at 1 year after smoking cessation in patients with less abdominal obesity. Thus, the beneficial effect of smoking cessation may outweigh the adverse effect of weight gain after smoking cessation.