Flexible Breathable Nanomesh Electronic Devices For On-Demand Therapy

Flexible electronics are drawing tremendous interest for various applications in wearable healthcare biomonitoring, on-demand therapy, and human-machine interactions. However, conventional plastic substrates with uncomfortableness, mechanical mismatches, and impermeability have limited the application of flexible on-skin electronic devices for healthcare biomonitoring and on-demand therapy. Herein, flexible breathable electronic devices with the capabilities of real-time temperature sensing and timely on-demand anti-infection therapy at wound sites are presented. These devices are assembled from a crosslinked electrospun moxifloxacin hydrochloride (MOX)-loaded thermoresponsive polymer nanomesh film with a conductive pattern. The conductive polymer nanomesh film demonstrates excellent flexibility, reliable breathability, and robust environmental stability. Furthermore, the assembled temperature sensor displays a linear relationship between the electrical resistance and temperature, potentially enabling real-time biomonitoring of tissue temperature at the wound site. Smart artificial electronic skins (E-skins) are assembled from the thermoresponsive polymer nanomesh film for spatial touching sensing mapping of temperature changes. Furthermore, the flexible temperature sensor is coupled with a wireless transmitter for real-time wireless temperature monitoring. Notably, the thermoresponsive polymer nanomesh film can also be assembled as a highly efficient flexible heater to trigger the on-demand release of antibiotics loaded in the fibers to eliminate bacterial colonization in the wound site once infection has occurred.