Urinary angiotensinogen in patients with urinary tract infection.

Background Urinary tract infection (UTI) is one of the most common diseases in children, and urinary angiotensinogen (U-AGT) is a new biomarker gathering attention in many renal diseases. U-AGT reflects intrarenal renin-angiotensin system (RAS) activity. We conducted a study to measure U-AGT in children UTI. Methods All children UTI group and a non-UTI group, and U-AGT was measured. Results Median U-AGT was higher in patients with UTI compared with patients without UTI: (0.56 ng/dL, range, 0.025-2.753 ng/dL vs 0.13 ng/dL, range, 0.008-1.697 ng/dL, respectively; P < 0.05). Conclusions U-AGT is elevated in UTI patients, and RAS activation may contribute to renal injury caused by UTI.