Downregulations of placental fatty acid transporters during cadmium-induced fetal growth restriction.

Toxicology(2019)

引用 13|浏览29
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摘要
•The FGR in Cd-treated mice is linked to the decreased placental TG level and the decreased expression levels of FATP1, FATP6 and FABP3.•The FGR in Cd-treated mice is not associated with the maternal supply.•The decreased expression levels of FATP1, FATP6 and FABP3 is associated with the p38-MAPK, p38 MAPK/PPAR-γ and HIF-1α pathways respectively.•The differential expression levels of FATP1, FATP6 and FABP3 were not correlated with the DNA methylation modification of the promoter regions.
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关键词
Acaca,Acacb,ACOX1,BCS1L,Cd,FA,FASN,FATP,FABP,FGR,HADHA,HIF-1α,LCPUFAs,NEFA,PCK1,PPAR-γ,qPCR,TC,TG
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