Synergic PDE3 and PDE4 control intracellular cAMP and cardiac excitation-contraction coupling in a porcine model

Delphine Mika,Pierre Bobin,Marta Lindner,Angele Boet,Amir Hodzic,Florence Lefebvre,Patrick Lechène,Malha Sadoune,Jane-Lise Samuel,Vincent Algalarrondo,Catherine Rucker-Martin,Virginie Lambert,Rodolphe Fischmeister,Grégoire Vandecasteele,Jérôme Leroy

Journal of Molecular and Cellular Cardiology（2019）

引用 16|浏览72

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摘要

•In pig ventricular myocytes, both PDE3 and PDE4 hydrolyze cAMP.•PDE4 inhibition produces inotropic effects and is pro-arrhythmic.•PDE3A, PDE4A, PDE4B, PDE4D expression is conserved in mouse, pig and human heart.•These conclusions also apply in a porcine model of right ventricular failure.

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