Integration of needle-free jet injection with advanced electroporation delivery enhances the magnitude, kinetics, and persistence of engineered DNA vaccine induced immune responses.

Jingjing Jiang,Stephanie J Ramos, Preeti Bangalore,Paul Fisher, Kristine Germar,Brian K Lee, Dan Williamson, Andrea Kemme, Eric Schade,Jay McCoy,Kar Muthumani,David B Weiner,Laurent M Humeau,Kate E Broderick

Vaccine（2019）

引用 14|浏览7

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摘要

•Electroporation enhances DNA muscle transfection over needle-free jet injection.•Adding EP to Jet delivery improves DNA vaccine induced immune responses in NHPs.•Enhanced antibody levels sustained at least 9 months post Jet-EP delivery in NHPs.

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关键词

DNA vaccine,Needle-free injection,Electroporation,Immunogenicity

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