Neural mechanisms of perceptual decision-making and their link to neuropsychiatric symptoms in multiple sclerosis.

Multiple Sclerosis and Related Disorders(2019)

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摘要
•Decision-making (DM) in well-studied DM domains is impaired in persons with MS.•Impaired DM is assumed to worsen the quality of life and neuropsychiatric symptoms.•Using a novel DM paradigm, we found that also perceptual DM is impaired in MS.•Neural mechanisms of perceptual DM are linked to depression and fatigue.•Neurobehavioral deficits in perceptual DM appear to be clinically relevant for MS.
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关键词
Multiple sclerosis,Perceptual decision-making,Neuropsychiatric symptoms,Task-based fMRI
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