Generation and functional characterization of Plasmodium yoelii csp deletion mutants using a microhomology-based CRISPR/Cas9 method.
International Journal for Parasitology(2019)
摘要
•Plasmodium yoelii can repair CRISPR/Cas9-generated DNA breaks by microhomology-mediated end joining.•Size mutants of the central repeat in circumsporozoite surface protein (CSP) were successfully generated.•A minimum size of the CSP central repeat region is required for mosquito stage development.
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关键词
Rodent malaria,MMEJ,Double strand break,Circumsporozoite surface protein,Mosquito
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