Selective inhibition of Aurora A and B kinases effectively induces cell cycle arrest in t(8;21) acute myeloid leukemia.

Jialei Qi,Xiang Gao,Xiaomin Zhong,Ninghan Zhang,Rong Wang,Huihui Zhang,Ting Pan,Xuejiao Liu,Yao Yao,Qingyun Wu,Mingshan Niu,Kailin Xu

Biomedicine & Pharmacotherapy（2019）

引用 11|浏览14

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摘要

•Aurora kinase A and B inhibitors suppress the proliferation of t(8;21) AML by inducing G2/M accumulation.•The t(8;21) AML cells are more sensitive to Aurora B inhibition compared with Aurora A.•This study provide novel approach to t(8;21) AML target therapy.

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关键词

Aurora kinase,AML-ETO,Acute myeloid leukemia,Alisertib,Barasertib

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