Su1096 – Calcium Signaling in the Regulation of Small Intestinal Glucose Absorption

Colorectal Cancer Registry.Individuals with hereditary cancer syndromes or inflammatory bowel disease were excluded.TaqMan® SNP Genotyping Assays for IL-1β (rs1143627), IL-6 (rs1800795), and IL-10 (rs1800871) and Gene Expression Assays (ThermoFisher) for these cytokines were performed according to the manufacturer's recommendations.Adjusted odds ratios (OR) were estimated using Logistic Regression Models.Results: Overall, the pro-inflammatory SNPs in IL-1β, IL-6 and IL-10 were most frequently detected in among individuals with CRC than in controls.Those with the heterozygous IL-6 SNP had 0.23 times (95% CI:0.06-0.93) the odds of having EO CRC and 2.43 times (95% CI:0.62-9.48)more odds of having LO CRC compared to those with the wild type (WT) genotype.Individuals with heterozygous IL-1β and IL-10 SNPs showed lower odds of having LO CRC (OR:0.60;95% CI:0.15-2.38 and OR:0.56; 95% CI:0.16-1.90, respectively), but higher odds of having EO CRC (OR:1.88;95% CI:0.38-9.34 and OR:2.67; 95% CI:0.72-9.92,respectively) when compared to WT. Homozygous IL-1β SNPs may increase the odds of CRC among EO CRC (OR:1.97;95% CI:0.42-9.33)and LO CRC (OR:1.65;95% CI:0.33-8.16).Conclusion: An evaluation of the association between pro-inflammatory SNPs in IL-1β, IL-6 and IL-10, and EO CRC using a larger sample size is warranted.Future research examining pro-inflammatory SNPs could provide information about host genetic susceptibility to develop EO CRC and could serve as the foundation for studies evaluating SNP-based risk stratification for individuals at a higher risk.