Habenula deep brain stimulation for refractory bipolar disorder
Brain Stimulation(2019)
摘要
Bipolar disorder (BD) is a mood disorder associated with significant morbidity and mortality. In many cases, BD can be managed with pharmacotherapy, psychological therapy, or electroconvulsive therapy [ [1] Grande I. Berk M. Birmaher B. Vieta E. Bipolar disorder. Lancet. 2016; 387: 1561-1572https://doi.org/10.1016/S0140-6736(15)00241-X Abstract Full Text Full Text PDF PubMed Scopus (830) Google Scholar ]. For some afflicted patients, however, BD is a chronic and severely disabling condition that is resistant to the aforementioned treatments. Deep brain stimulation (DBS) offers a safe and effective neurosurgical treatment for otherwise refractory movement disorders and obsessive-compulsive disorder [ [2] Krack P. Hariz M.I. Baunez C. Guridi J. Obeso J.A. Deep brain stimulation: from neurology to psychiatry?. Trends Neurosci. 2010; 33: 474-484https://doi.org/10.1016/j.tins.2010.07.002 Abstract Full Text Full Text PDF PubMed Scopus (223) Google Scholar , [3] Williams N.R. Okun M.S. NR W. MS O. Deep brain stimulation (DBS) at the interface of neurology and psychiatry. J Clin Investig. 2013; 123: 4546-4556https://doi.org/10.1172/JCI68341 Crossref PubMed Scopus (86) Google Scholar ]. Here, we describe the first case of refractory BP treated effectively with DBS of the habenula (HB).
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deep brain stimulation
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