S125. Subjective and Behavioral Effects of Microdoses of LSD in Healthy Human Volunteers

There have been numerous anecdotal reports that very low doses of lysergic acid diethylamide (LSD) reduce depressed mood and improve positive outlook. Yet, the effects of such “microdoses” have not been tested under double-blind, placebo-controlled conditions. As a first step, we examined the subjective and behavioral effects of single low doses of LSD in healthy adults.