The NLRP1 inflammasome: new mechanistic insights and unresolved mysteries
Current Opinion in Immunology（2019）
摘要
•NLRP1 is a sensor of diverse pathogen-encoded activities.•‘Functional degradation’ provides a mechanism for NLRP1 activation.•New insights into NLRP1 have been revealed by non-pathogen triggers, including Val-boroPro and auto-active disease-associated human mutations.•CARD8 is a novel NLRP1-like inflammasome.
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