42. Inhibiting Ventral Dentate Gyrus Activity Can Prevent Stress-Induced Psychopathology in Mice

Christoph Anacker,Victor Luna,Amira Millette,Gregory Stevens,Rene Hen

Biological psychiatry（2019）

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摘要

We have shown that hippocampal neurogenesis can confer stress resilience by inhibiting ventral dentate gyrus (vDG) activity. How inhibition affects information processing in the vDG, and whether inhibition could prevent the development of psychiatric disorders is unknown.

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关键词

Ventral Hippocampus,Neurogenesis,Serotonin 1A Receptor,Chronic Stress,Resilience and Vulnerability

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