Toward Broad Spectrum DHFR inhibitors Targeting Trimethoprim Resistant Enzymes Identified in Clinical Isolates of Methicillin-Resistant Staphylococcus aureus

Jolanta Krucinska
Jolanta Krucinska
Yongzhao Yan
Yongzhao Yan
Siyu Wang
Siyu Wang
Graham T Holt
Graham T Holt
Marcel S Frenkel
Marcel S Frenkel
Adegoke A Ojewole
Adegoke A Ojewole
Sherry S Agabiti
Sherry S Agabiti

bioRxiv, pp.648808-34, (2019)

Cited by: 0|Views5
WOS

Abstract:

The spread of plasmid borne resistance enzymes in clinical Staphylococcus aureus isolates is rendering trimethoprim and iclaprim, both inhibitors of dihydrofolate reductase (DHFR), ineffective. Continued exploitation of these targets will require compounds that can broadly inhibit these resistance-conferring isoforms. Using a structure-ba...More

Code:

Data:

ZH
Your rating :
0

 

Tags
Comments