Acute Inflammation And Attentional Bias For Threat Following Salmonella Typhi Vaccine

In animal models, acute inflammation elicits behaviors related to psychiatric symptoms, including exaggerated threat sensitivity. Less is known about the effects of acute inflammation on the brain and behavior in humans. The polysaccharide form of the Salmonella Typhi vaccine elicits an acute inflammatory response and may provide a useful tool for clinical psychiatry research. Here, we examined the effects of typhoid vaccine on immune cells, cytokines, and attentional bias towards threat.