S196. Cerebellar Endocannabinoid Down-Regulation Accompanies Early Life Stress Induced Facilitation of Eyeblink Conditioning

Alexandra Moussa-Tooks,John Green,Ken Mackie,Alex Gimeno,Eric Larson,Heather Bradshaw,Emma Leishman,Brian O'Donnell,William Hetrick

Biological psychiatry（2019）

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摘要

Early life stress (ELS) impacts neurodevelopment during critical periods, conferring risk for various psychopathologies, such as psychosis, substance use, and/or anxiety. One potential mechanism is through the endocannabinoid system, integrated in the stress response circuit.

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关键词

Early Life Stress,Cerebellum,Endocannabinoids,Sex Differences,Research Domain Criteria (RDoC)

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