P36-S Validation of near fiber motor unit potential stability and dispersion measures using simulated signals
Clinical Neurophysiology(2019)
摘要
A motor unit potential (MUP) is the summation of the muscle fiber potentials (MFPs) generated by the fibers of its MU. A near-fiber (NF) MUP is the summation of MFPs from fibers near the recording electrode. The temporal consistency and dispersion of NF MFP contributions can be clinically useful. NF MUP jiggle and NF MUP segment jitter are new measures of MFP temporal consistency and NF duration and NF dispersion are new measures of MFP temporal dispersion. Simulated EMG models provide a controlled scenario for validating the overarching capabilities of these new NF MUP measures. A commercial EMG simulator (Karlsson and Stalberg, version 3.6) generated 120 EMG signals each comprised of 4 motor unit potential trains (MUPTs). Across these signals, MU size varied between 100 to 300 fibers, MFP jitter ranged from 20 to 80 μs and three different recording electrode to endplate distances (5, 20 and 55 mm) were used. MUPTs were extracted from the EMG signals and analyzed using DQEMG. NF MUP jiggle and NF MUP segment jitter show high accuracy in evaluating NF MFP jitter. NF-MUP duration and dispersion offer accurate information about MU morphology (i.e. dispersion of fiber end plate locations and varying conduction velocities). The new NF MUP measures accurately represent useful electrophysiological and morphological aspects of their corresponding MUs. DQEMG offers a comprehensive evaluation of motor unit electrophysiological stability and morphology that can assist with the diagnosis of neuromuscular diseases.
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关键词
fiber motor unit,dispersion measures,potential stability
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