In vivo and in vitro anti-inflammatory and pro-osteogenic effects of citrus cystatin CsinCPI-2.

Natalia Da Ponte Leguizamón,Elisandra Marcia Rodrigues,Michel Leandro de Campos,Andressa Vilas Boas Nogueira,Kennia Scapin Viola,Vanessa Karine Schneider,Daniela Morilha Neo-Justino,Mario Tanomaru-Filho,Willian Fernando Zambuzzi,Flavio Henrique-Silva,Andrea Soares-Costa,Gisele Faria,Joni Augusto Cirelli

Cytokine（2019）

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摘要

•New phytocystatin identified in Citrus sinensis: CsinCPI-2.•CsinCPI-2 presents inhibitory activity on human cathepsin K.•It inhibits inflammatory cathepsins and cytokines in vitro in mouse.•CsinCPI-2 shows an inhibitory effect on the activity of TNF-α in rats.•CsinCPI-2 has pro-osteogenic effect in human dental pulp cells.

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关键词

Cystatins,Cysteine proteinases,Cytokines,Cathepsins

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