Increased precision in the intravascular arterial input function with flow compensation.

Purpose: In this study, we investigate the effects of pulsatile flow and inflow on dynamic susceptibility-contrast MRI intravascular arterial input function measurement in human brain arteries and measure how they are affected by first-order flow compensation. Methods: A dual-echo single-shot EPI sequence with alternating flow compensation gradients was used to acquire dynamic susceptibility-contrast images with electrocardiogram monitoring. The dynamic signal variations measured inside the middle cerebral and internal carotid arteries were associated to the pulsatile arterial blood velocities measured with a single-slice quantitative flow sequence throughout the cardiac cycle. Results: Major inverse correlations between intravascular signal and blood velocity were found for the standard single-shot EPI sequence. Flow compensation reduces these correlated variations that contribute to signal physiological noise. This causes a significant twofold increase of intravascular SNR in the middle cerebral and the internal carotid arteries (2.3 +/- 0.9, P = 0.03) and (2.0 +/- 0.9, P = 0.04), respectively; and reduced phase SD for the internal carotid arteries (0.72 +/- 0.14, P = 0.004). The correction proposed in this work translates into a quantitative arterial input function with reduced noise in the internal carotid arteries. Conclusion: The physiological noise added by pulsatile flow and inflow for intravascular arterial input function measurement in the brain arteries is significantly reduced by flow compensation.