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The ubiquitin-specific protease USP8 directly deubiquitinates SQSTM1/p62 to suppress its autophagic activity.

AUTOPHAGY, no. 4.0 (2020): 698.0-708

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Abstract

SQSTM1/p62 (sequestosome 1) is a critical macroautophagy/autophagy receptor that promotes the formation and degradation of ubiquitinated aggregates. SQSTM1 can be modified by ubiquitination, and this modification modulates its autophagic activity. However, the molecular mechanisms underpinning its reversible deubiquitination have never be...More

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Author
Fang Yang
Fang Yang
Qianwen Hu
Qianwen Hu
Jian Sun
Jian Sun
Cheng Peng
Cheng Peng
Yao Zhao
Yao Zhao
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