Structural knowledge or X-ray damage? A case study on xylose isomerase illustrating both

JOURNAL OF SYNCHROTRON RADIATION, pp. 931-944, 2019.

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Abstract:

Xylose isomerase (XI) is an industrially important metalloprotein studied for decades. Its reaction mechanism has been postulated to involve movement of the catalytic metal cofactor to several different conformations. Here, a dose-dependent approach was used to investigate the radiation damage effects on XI and their potential influence o...More

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