O-GlcNAcylation-dependent upregulation of HO1 triggers ammonia-induced oxidative stress and senescence in hepatic encephalopathy.

Boris Görg,Ayse Karababa,Elina Schütz,Martha Paluschinski,Alina Schrimpf,Aygul Shafigullina,Mirco Castoldi,Hans J Bidmon,Dieter Häussinger

Journal of Hepatology（2019）

引用 42|浏览9

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摘要

•Ammonia triggers protein O-GlcNAcylation in astrocytes via synthesis of GlcN.•O-GlcNAc-dependent upregulation of HO1 + Nox4 induces RNA oxidation and senescence.•Protein O-GlcNAcylation is increased in the brains of cirrhotic patients with HE.

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关键词

Glutamine,Glucosamine,Ferrous iron,RNA oxidation,Senescence

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