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A Potent Free Fatty Acid Receptor 1 Agonist with a Glucose-Dependent Antihyperglycemic Effect.

Xuekun Wang,Yurui Xu,Shujun Feng,Xinyu Huang,Xia Meng,Jiao Chen,Leilei Guo,Junliang Ge,Jikang Zhang,Jianmei Chen,Li Cheng,Kai Gu,Yu Zhang,Qing Jiang,Xinghai Ning

Chemical communications（2019）

Cited 4|Views14
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Abstract
We present a novel free fatty acid receptor 1 (FFA1) agonist, named PAFA, with a strong agonist potency (EC50 = 6.04 nM) and good serum stability. PAFA significantly stimulates insulin secretion in INS-1 cells in a glucose-dependent manner and exhibits high antihyperglycemic effects in db/db mice without adverse effects.
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