Single Cell Analysis Of Acquired Pomalidomide-Resistance In Multiple Myeloma Cell Lines Reveals Distinct Subclonal Cereblon Mutations And Gene Expression Heterogeneity

Background: Multiple myeloma (MM) is a clonally heterogeneous cancer that recurrently relapses during its clinical course, demonstrating how interplay among subclones can lead to differentially drug-tolerant populations. The determination of onset and mechanisms of drug resistance is of clinical interest, and the improved understanding of this will drive innovative therapeutic approaches.