Unraveling the evolutionary origin of ELR motif using fish CXC chemokine CXCL8

Krishnakant Gangele
Krishnakant Gangele
Minal Jamsandekar
Minal Jamsandekar

Fish & shellfish immunology, Volume 93, 2019, Pages 17-27.

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Keywords:
CXCL8ChemokinesInterleukin-8Molecular evolutionNeutrophil activating chemokinesMore(1+)

Abstract:

Chemokines are chemotactic proteins involved in host defense through the migration of immune-regulatory cells to the site of infection. Interleukin-8 (CXCL8/IL8) is the most studied "ELR-CXC chemokine/neutrophil activating chemokine (NAC) that regulate neutrophil trafficking during infections and inflammation by binding to its cognate G-p...More

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