The relative efficiency of time-to-progression and continuous measures of cognition in presymptomatic Alzheimer's disease.

Dan Li,Samuel Iddi,Paul S Aisen,Wesley K Thompson,Michael C Donohue

Alzheimer's & Dementia: Translational Research & Clinical Interventions（2019）

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摘要

Given the relative inefficiency of time to progression, it should be avoided as a primary analysis approach in clinical trials of preclinical Alzheimer's disease.

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关键词

Clinical trial simulations,Alzheimer's disease,Cox proportional hazards model,Longitudinal data,Mixed model of repeated measures (MMRM),Statistical power,Common close design,Bayesian joint mixed-effect model

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