Design, synthesis, biological and in silico evaluation of coumarin-hydrazone derivatives as tubulin targeted antiproliferative agents.

•Syntheiszed different sets of coumarin based hydrazone derivatives.•All the compounds were characterised by FT-IR, NMR and ESI-MS spectroscopic methods.•Evaluated for antiproliferative activity against different cancer cell lines (A549, HeLa, SKNSH, and MCF7).•Tubulin polymerization inhibition assay was performed and compared with standard drug colchicine.•The tubulin polymerization inhibition assay results were validated with molecular docking simulation study with the tubulin protein retrieved from protein data bank (PDB ID: 4YJ3).•All the synthesized compounds molecular properties and pharmacokinetic properties were predicted by using some online servers and software’s.